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Wheat
 RE: IRC highlights!
 

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sensually

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04-17-2016, 01:14 AM
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btp
 RE: IRC highlights!
like a wild, sexy Dick Cheney

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I agree.
04-17-2016, 01:16 AM
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Papers
 RE: IRC highlights!
 

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Code:
22:47    Papers    hi
22:47    DragonFogel    Hi, we're playing cards.
22:47    Papers    i'm in
22:48    SlimeMan    no you're papers
22:49    Papers    fuck
22:49    Papers    you got me
22:49    Jacquerel    (hacker void) i'm papers
22:49    Jacquerel    voice
22:51    Papers    hahahah

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(This post was last modified: 04-17-2016, 02:51 AM by Papers.)
04-17-2016, 02:51 AM
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Wheat
 RE: IRC highlights!
 

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i like that you put it in code

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04-17-2016, 07:41 AM
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Papers
 RE: IRC highlights!
 

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I did that for the monospacing, but in retrospect I could've just set the font to Courier

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04-17-2016, 08:20 AM
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Wheat
 RE: IRC highlights!
 

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no it's better because it's a code log for hackers

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04-17-2016, 07:11 PM
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Schazer
 RE: IRC highlights!
Patron Saint of Normcore

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Science chat with Sanzh Schaz and Sfou:
Spoiler :
<schazer> so out of curiosity Sanzh
<schazer> what kind of thing are you trying to lay a claim on exactly
<schazer> is it a meme
<schazer> are you trying to patent a meme
<TheBlueAvenger> You should patent a meme.
<sfou> glorious
<sfou> just slap a 2 million dollar lawsuit on anyone who posts a misspelled lolcat
<schazer> parody is a thing though
<Sanzh> "A method of increasing yield of active protein during translation of a protein from a source organism in a heterologous host by adjusting translation kinetics of mRNA encoding the protein"
<schazer> fuck ok lemme uh
<TheBlueAvenger> ...wow.
<Sanzh> lol
<schazer> go get coffee so I cna read that without my eyeballs sliding off it
<TheBlueAvenger> Like,
<Sanzh> ha ha welcome to my life
<Sanzh> at least I'm using my degree
<TheBlueAvenger> I know what those words mean individually
<TheBlueAvenger> but all together?
* TheBlueAvenger shakes her head grimly
<schazer> what is "active protein"
<schazer> is that like, enzymes, or stuff that does shit rather than being structural ,or
<Sanzh> it's like activated almonds
<schazer> lmao
<schazer> so best as I understand this
<Sanzh> http://www.google.com/patents/US20130149699
<schazer> this is micro-viagra for mRNA
<Sanzh> here's the application
<schazer> that makes it get jiggier with the ribosomes
<Sanzh> i think so
<Sanzh> it's made by the guy who discovered RNA interference
<schazer> so you get more activated almonds out of your amino acid soup
<Sanzh> i think it's like that, yeah
<schazer> is the viagra an actual chemical, or a training regime, or some kind of prayer
<sfou> you missed the part about hetrologous hosts
<sfou> and translation kinetics
<schazer> "translation kinetics" is to my understanding, the physical properties of the molecules that are involved in the translation process
<sfou> so like
<Sanzh> i'll be honest schazer
<Sanzh> i have no fuckin' idea
<sfou> throw the protein harder at the thing and it will eat more protein
<sfou> it's basically like a nourishment bullet
<schazer> wherein translation is where you feed a strand of mRNA (butt or face) through a ribosome (photocopier) which uses those instructions to join up a specific chain of amino acids (2 dimensional rendition of butt or face) which then becomes folded into a protein (paper airplane)
<sfou> a device to fire high-velocity nourishment bullets
<sfou> the hunger-sniper
<schazer> this is my high quality science metaphor
<schazer> I'm laying a claim on this shit do not steal
<schazer> so translation kinetics is like, maybe, in this case, a stool
<schazer> so it's easier to get on and off the photocopier safely
<sfou> wait
<sfou> doesn't it just mean that you slam your face or butt harder at the photocopier
<sfou> or like, just adjust the speed and angle
<schazer> no, because that'll damage the mRNA
<schazer> I really think this is some kind of stepladder he's invented
<schazer> or maybe handrails to hold onto
<sfou> like gently rub your buttcheeks against the glass without squishing them so that you get a good 3D image rather than an inferior squished copy
<schazer> I dunno, I think part of the charm of photocopying your face/butt is to get the squished look
<schazer> like if you wanted an accurate rendition you should just take a photo
<sfou> but then you wouldn't need the handles you could just sit on the thing
<sfou> and there's no need for a patent
<schazer> no, this is about making the copying process easier
<schazer> it's already possible, but we've invented a thing to make it more efficient
<sfou> ahh! i get ya.
<schazer> so, a stepladder/stool so you can get on and off the photocopier easier
<schazer> so you can hit the controls to actually print it properly
<sfou> beautiful
<schazer> Sanzh how many standard amino acids out of 20 do you give my explanation
<sfou> brb
<schazer> oh ok! I just looked up what heterologous hosts are
<schazer> they are cells that are producing a mRNA sequence->amino acid sequence->protein that it normally wouldn't
<schazer> so someone's genetically engineered the thing so it has this "foreign" DNA in it
<schazer> a fantastic example is E. coli producing insulin
<Sanzh> i'm gonna go grab dinner
<Sanzh> see you guys later :>
<schazer> Sanzh no
<schazer> wait
<schazer> tell me how good my science is
<Sanzh> iunno
<schazer> aw
<Sanzh> i'd say like maybe an aspartic acid out of 20
<schazer> woooooooo
← Sanzh has quit (Quit: http://www.mibbit.com ajax IRC Client)
04-20-2016, 12:43 AM
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btp
 RE: IRC highlights!
like a wild, sexy Dick Cheney

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Schazer Wrote:<schazer> wherein translation is where you feed a strand of mRNA (butt or face) through a ribosome (photocopier) which uses those instructions to join up a specific chain of amino acids (2 dimensional rendition of butt or face) which then becomes folded into a protein (paper airplane)
Oh my god you have just revolutionized the way I teach translation from now on.
04-20-2016, 01:14 AM
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Schazer
 RE: IRC highlights!
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ur welcome
04-20-2016, 01:20 AM
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Papers
 RE: IRC highlights!
&nbsp;

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Make sure to actually pull a paper airplane out for your desk and throw it across the room. Whoever picks it up and unfolds it will see a very simple drawing of a butt:

)(

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04-20-2016, 03:59 AM
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Schazer
 RE: IRC highlights!
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The take-away is that "correct object photocopied in the right way" (non-garbled DNA sequence, transcripted/copied into a non-garbage mRNA sequence) when folded correctly, might result in an interesting/cohesive pattern on the wing surface (correctly-"shaped" regions of the protein so it does the thing it was designed to do) when the resulting sheet of paper (polypeptide) is folded into a plane (protein).

A garbage DNA sequence (haphazard ass on xerox), conversely, could still produce a polypeptide (printout), but folding it up just results in a paper airplane that doesn't even look cool and rubs off photocopier ink onto your fingers when you handle it.
04-20-2016, 04:09 AM
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Papers
 RE: IRC highlights!
&nbsp;

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So you're saying one would have to use their graphic design skillz to make a butt that folds up into a cool something else

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04-20-2016, 04:26 AM
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Schazer
 RE: IRC highlights!
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Well, ribosomes (the cellular machine that, via translation, makes a tangible product out of lines of code) produce a polypeptide according to the mRNA sequence that got fed through them.

The polypeptide is a chain of amino acids, and amino acids are just molecules. Different points in the chain have different dangly bits, different regions that repel or attract and generally restrict the polypeptide from scrunching up however the fuck it pleases.

The specific chemical/atomic/molecular properties of the polypeptide chain (similar properties that cause water and oil to not mix unless you add soap) will dictate how it folds up, kind of like how:
[Image: cup_crease.jpg]
are the exact lines you fold in a sheet of paper to produce a cup which Actually Holds Real Water. Put seven creases in different positions on the paper and you're either going to get something Less Good At Holding Water, something which Can't Hold Water For Shit, or maybe even something That Does Something Really Good That Isn't Holding Water*.

To distort the metaphor somewhat for the sake of scientific clarity, imagine photocopying something 3-dimensional (butt, face, artfully arranged collection of office stationery) then folding along the lines on the resulting 2-dimensional printout. Most of the time, according to your rules (in the photocopier metaphor, artistic license and consistent decisions about what constitutes a "fold line"; in gene expression, chemical/physical properties like activation energy/hydrophilic or -phobic regions), you're just going to get crumpled-up bullshit. Photocopy a cup and you're not going to get a piece of paper that intuitively folds into a cup.


*Obviously, in origami, the order in which you make the creases is just as important - this applies somewhat to proteins too; many "organelles" in the cell (chiefly the golgi bodies, and the rough and smooth endoplasmic reticulums) act as micro-"climates" that make certain amino acids in the chain more or less disposed to repel/attract, or certain regions to end up on the "inside" or "outside" of the resulting molecule.
04-20-2016, 04:58 AM
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NonAnalogue
 RE: IRC highlights!
Stay fresh!

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I am not nearly competent enough in science to be able to comment on this, but I will say that this sort of thing makes me super-glad I joined these forums.

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04-20-2016, 01:35 PM
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Papers
 RE: IRC highlights!
&nbsp;

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04-20-2016, 05:31 PM
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Plaid
 RE: IRC highlights!
super gay

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snugged up in bed
Thats certainly a new look for Daisy

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04-21-2016, 04:22 AM
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btp
 RE: IRC highlights!
like a wild, sexy Dick Cheney

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CardsAgainstHawkspace Wrote:<Granola> I assumed mine was an std. instead it's a lizard. learn something new every day

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The card was Gharials.
04-22-2016, 02:14 AM
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Papers
 RE: IRC highlights!
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do you have car?

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04-24-2016, 04:21 AM
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Dragon Fogel
 RE: IRC highlights!
The Goddamn Pacman

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<DragonFogel> Bob, am I destroying your grasp of language?
<btp__> You are destroying several things
<btp__> like my tolerance for space consortiums
04-24-2016, 06:22 AM
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NonAnalogue
 RE: IRC highlights!
Stay fresh!

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[20:11:18] <Mjiler> if its as simple as capitalization i'm gonna feel pretty dumb
[20:12:04] <cyber95_> it was as simple as capitalization
[20:12:11] <Mjiler> i feel pretty dumb

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04-26-2016, 12:12 AM
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Dragon Fogel
 RE: IRC highlights!
The Goddamn Pacman

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<DragonFogel> Also, Sol, I just stumbled on something you said that I was saving for an "I told you so" but apparently you told me so instead.
<DragonFogel> <Solaris> theres no way that theres like
<DragonFogel> <Solaris> more than a year of homestuck left
<Solaris> ok look
<DragonFogel> Said on June 6 last year.
<Solaris> i think
<Solaris> that we'll both win
<Solaris> because homestuck is over but it has an epilogue
<Solaris> that said, wow how the fuck was i right
04-29-2016, 06:01 PM
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Papers
 RE: IRC highlights!
&nbsp;

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we have one month. will fogel get his consolation prize? find out next time!

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04-29-2016, 07:46 PM
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Reyweld
 RE: IRC highlights!
zip

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Canadon't know please send help
yes .

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Spoiler :
(03-02-2015, 02:07 AM)Papers Wrote: i don't know what i expected from reyweld's new hawkspace thread
(06-02-2016, 04:16 AM)Schazer Wrote: Tokyo could kick your scrawny ass
04-30-2016, 03:18 AM
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Papers
 RE: IRC highlights!
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04-30-2016, 05:43 AM
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Reyweld
 RE: IRC highlights!
zip

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Canadon't know please send help
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Spoiler :
(03-02-2015, 02:07 AM)Papers Wrote: i don't know what i expected from reyweld's new hawkspace thread
(06-02-2016, 04:16 AM)Schazer Wrote: Tokyo could kick your scrawny ass
04-30-2016, 11:30 AM
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